Interface-dependent electric-pulse-induced resistance switching effect (EPIR) in Nd_0.7Sr_0.3MnO₃ ceramics was studied. The results reveal that the EPIR effect originates from the interface between the electrodes and the bulk, and the EPIR ratio as well as the high and low resistance states can be strongly influenced by applying a large electrical field on the sample for different intervals. Also, the pulse parameters have great effect on the stability of EPIR and the optimal pulse width, pulse amplitude and read bias are obtained. Based on the space charge limited current mechanism together with the theory of interfacial charge-trapped state, the interface-dependent resistance switching effect is discussed.