• G Krithiga

      Articles written in Bulletin of Materials Science

    • In vitro study on biomineralization of biphasic calcium phosphate biocomposite crosslinked with hydrolysable tannins of Terminalia chebula

      G Krithiga Antaryami Jena P Selvamani T P Sastry

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      In this study, we report the preparation of a bone graft material, having cylindrical shape, containing biphasic calcium phosphate (BCP), gelatin (G), chitosan (C) and Terminalia chebula (TC) extract. TC extract was used as a crosslinker that gives stability to bone graft when it is placed in SBF. The graft was stable in the SBF solution for 21 days and FTIR, SEM, EDX and thermogravimetric studies revealed the ossification of the implant.

    • A novel wound dressing material — fibrin–chitosan–sodium alginate composite sheet

      M Pandima Devi M Sekar M Chamundeswari A Moorthy G Krithiga N Selva Murugan T P Sastry

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      The present study describes preparation and characterization of fibrin–chitosan–sodium alginate composite (F–C–SA) in sheet form. F–C–SA composite was prepared and characterized for its physicochemical properties like water absorption capacity, surface morphology, FTIR spectra and mechanical properties. The optimum quantities of fibrin, chitosan and sodium alginate to get better mechanical properties to composite were determined. FTIR spectrum confirmed the interaction between amino groups of chitosan, fibrin and sodium alginate and SEM studies revealed composite nature of the material.

    • Study on osteopotential activity of Terminalia arjuna bark extract incorporated bone substitute

      G Krithiga T Hemalatha R Deepachitra Kausik Ghosh T P Sastry

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      Bark extract of Terminalia arjuna (TA) possesses potent medical properties and therefore, holds a reputed position in both Ayurvedic and Unani systems of medicine. Bone substitutes play an inevitable role in traumatic bone damages. Growth factors induce osteoinductivity, but suffer from limitations such as high cost and side effects. This study aims to evaluate the osteoinductive potential of bark extract of TA in bone substitutes. Bone substitutes prepared with TA bark extract were characterized for their physicochemical properties. In vitro biomineralization study was carried out using simulated body fluid. Cytotoxicity, alkaline phosphatase activity and mineralization potential were assessed using MG-63 cell lines. Scanning electron microscope revealed apatite formation on the surface after biomineralization. Thermogravimetric analysis showed 15% increase in residual weight by deposition of calcium and phosphate and their presence was identified by energy dispersive analysis. Increased alkaline phosphatase and calcium release was observed in bone substitutes prepared with TA extract compared with control. The functional groups of TA bark extract help in in vitro biomineralization. In MG-63 cells, it showed potential influence in cell differentiation. TA extract may be used as low-cost alternative for growth factors for treatment of fractured bones.

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    • Dr Shanti Swarup Bhatnagar for Science and Technology

      Posted on October 12, 2020

      Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
      Chemical Sciences 2020

      Prof. Surajit Dhara — School of Physics, University of Hyderabad, Hyderabad
      Physical Sciences 2020

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      Posted on July 25, 2019

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