Articles written in Bulletin of Materials Science

    • Isoimperatorin-mediated green-synthesized silver nanoparticles: antibacterial, antioxidant, cytotoxicity, hemolytic and coagulation effects


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      The isolated and pure biological compounds have been widely used in natural-based nanoparticles, entailing applications in medicine, cosmetics and nutrition. In this study, the toxic effects (in vitro) and biomedical applications of isoimperatorin-mediated green synthesized silver nanoparticles (Iso-AgNPs) were investigated. The in vitro antioxidant, antibacterial and cytotoxic potential were determined by using standard protocols. Besides, blood compatibility was determined by hemolysis and coagulation tests. Based on the obtained results, Iso-AgNPs showed enhanced antioxidant capacity in comparison with the crude isoimperatorin and were found effective against the pathogenic bacterial strains.Cell viability study reveals the safety of Iso-AgNPs on H1299 and MCF-7 cell lines, and no significant cytotoxicity was observed. The non-hemolytic effect of Iso-AgNPs on erythrocyte cells (RBCs) and the absence of coagulation indicate high blood compatibility of these nanoparticles, which make them unique in comparison to the other silver nanoparticles. Altogether, our finding confirms the biological advantages of Iso-AgNPs as a cyto- and blood-compatible antibacterial and antioxidant nano-metal.

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