Chandra P Sharma
Articles written in Bulletin of Materials Science
Volume 5 Issue 2 June 1983 pp 103-109
This paper reports our attempts to crosslink low molecular weight proteins namely trypsin and insulin using glutaraldehyde on polycarbonate surface and to evaluate how such surfaces may affect the blood compatibility of the polymer, by studying the interfacial energies of the modified polymer surface using advancing contact angle technique. The plasma recalcification time and platelet adhesion studies were also carried out. It has been observed that such low molecular weight proteins retard clotting.
Volume 5 Issue 2 June 1983 pp 127-131
Thrombus formation on a foreign surface is a complicated process, involving many factors. The adhesion and aggregation of platelets play an important role in the initial events of thrombus formation on such surfaces. In this work, adsorption/absorption studies using saturated fatty acids were carried out on polycarbonate surface to evaluate how such surfaces may affect blood-polymer interaction. The surface change was investigated by measuring the interfacial energies as derived from advancing contact angle technique. The plasma recalicification time and platelet adhesion studies were also carried out to further develop an understanding.
Volume 6 Issue 6 December 1984 pp 1087-1091
The surface modification of medical grade polyvinylchloride (
Volume 7 Issue 1 March 1985 pp 71-73
An attempt is made to develop the hydrophilic grafting of polyether urethane urea with hydroxyethyl methacrylate (
Volume 7 Issue 1 March 1985 pp 75-77
An effort is made to study the anti-thrombogenic property of the latex of fig tree by immobilizing its components on nylon surface. It is also evaluated, how such surfaces may effect the blood compatibility by investigating variations in surface energy parameters, plasma recalcification time and platelet adhesion using calf’s blood.
Volume 7 Issue 1 March 1985 pp 79-81
An attempt is made to immobilize low molecular weight trypsin on nylon surface and to evaluate how such surfaces affect blood compatibility by investigating variations in surface energy parameters, plasma recalcification time and platelet adhesion using calf’s blood.
Volume 17 Issue 6 November 1994 pp 1065-1070
Poly(vinyl alcohol) is a hydrogel which is extensively studied for a variety of biomedical applications. Membranes developed from crosslinked poly(vinyl alcohol) (PVA) is having excellent permeability to solutes. However its wet breaking strength is low. Polyetherurethaneurea (PEUU), having an excellent mechanical strength is blended with PVA as a reinforcement, and membranes developed are studied for its permeability and mechanical strength. The optimum membrane selected, is having permeability and wet breaking strength almost equal to the commercially available cellulose acetate membrane.
Volume 17 Issue 7 December 1994 pp 1317-1329
The fundamental concepts related to biomaterials and blood/tissue-material interactions at the interface have been reviewed. The relevance of surface modification to enhance blood and/or tissue compatibility of materials has been discussed and its role in selected prosthetic applications described.
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