• AMIT KUMAR SINGH

      Articles written in Bulletin of Materials Science

    • Magnetotactic curcumin iButtonbots as efficient bactericidal agents

      TAMANNA BHUYAN AMIT KUMAR SINGH SIDDHARTHA SANKAR GHOSH DIPANKAR BANDYOPADHYAY

      More Details Abstract Fulltext PDF

      The microbial contamination of drinking water is one of the most major concerns of community health in the developing world. Numerous water-borne pathogens are rapidly evolving and becoming resistant to traditional antibiotics.To get an efficacious bactericidal response, an assembly of several antibiotics or increased dosage are being administered, which may produce adverse side effects after prolonged use. Here, we describe a proficient method for disinfecting waterborne coliform bacterial strains of Escherichia coli DH5$\alpha$ from contaminated water samples using magnetic microbotsdecorated with curcumin (CU) conjugates. These magnetic microbots, namely, iButtonbots were composed of soft Agaricus bisporus (button mushroom) microcapsules with inherit antimicrobial properties. The locomotives were coated with magnetite nanoparticles for their remote guidance towards cells and collection along with CU for more enhanced bactericidal response. CU, a major active constituent of the Indian dietary spice turmeric and edible button mushrooms are known to exhibit antimicrobial activity against a wide range of bacterial species. The synergic antibacterial effect of CU and mushroomconstituents, imparts a profound bactericidal property to these magnetic microbots.We have demonstrated that microbots are capable of efficiently killing majority of bacterial cells in contaminated water samples. After extermination of bacteria, magnetic properties of embedded magnetite nanoparticles in porous mushroom matrix, allows collection of microbots from water samples. The presented biocompatible microbots offer an innovative method for rapid decontamination of bacteria-laden drinking water samples.

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