• ALINA GRACIA

Articles written in Bulletin of Materials Science

• Characteristic of Ag/TiO2–SiO2 bionanocatalysts prepared by sol–gel method as potential antineoplastic compounds

In this study, bionanocatalysts composed of a titanosilicate oxide matrix (TiO$_2$–SiO$_2$) impregnated with different concentrations of silver (0.1, 0.5, 1.0, 5.0 and 10 wt%) were prepared by the sol–gel method using silver nitrate(AgNO$_3$) as silver (Ag) source. The physicochemical properties were evaluated by scanning and transmission electron microscopies, Raman and Fourier transform infrared spectra, X-ray photoelectron spectra, and UV–visible spectroscopy.Furthermore, we studied the cytotoxic effect on a cervical uterine cancer cell line as a first approach attending to the potential antineoplastic properties of the Ag/TiO$_2$–SiO$_2$ bionanocatalysts. The bionanocatalysts exhibited no significant differences in morphology or composition independently of the amount of Ag stabilized, with a reduction in particle size proportional to Ag concentration. All samples could achieve cell mortality rates above 91%, obtaining results similar tothose of pure AgNO$_3$ (considered as 100% Ag) from the sample loaded with 1% Ag. The results in this study suggest the possibility of using bionanocatalysts to enhance the intrinsic cytotoxic properties of silver such that a minimum concentration is required to achieve desired results.

• # Bulletin of Materials Science

Volume 46, 2023
All articles
Continuous Article Publishing mode

• # Dr Shanti Swarup Bhatnagar for Science and Technology

Posted on October 12, 2020

Prof. Subi Jacob George — Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru
Chemical Sciences 2020