Amhassis commersoni was treated with 3 different concentrations (0·1, 0·25 and 0·5 ppm) of cadmium upto 120 days. Fishes treated in higher concentrations developed vertebral deformity and the deformation was prominent after 89th and 115th day. The levels of the vertebral minerals such as calcium, magnesium and phosphorus lowered in all exposure concentrations and minerals lost were directly proportional to the toxic concentrations. Nearly 2/3 of skeletal mineral composition was eliminated in the deformed fish. Vertebral fracture was attributed mainly to the large amount of vertebral components eliminated from the vertebrae. Vertebral cadmium accumulation was also linear in relation to the experimental concentrations.