In this paper, the seasonal fluctuations in adrenal glands and its relationship with their body weights, reproduction activity and population density of soft-furred field rat,Rattus meltada pallidior in the Indian desert has been discussed. Results of the present study revealed that the left adrenal gland in both the sexes of rodents was found to be significantly heavier (P<0·01) than the right one. The paired adrenal of female rats was significantly heavier (F<0·001) than those of males. The seasonal variations in adrenal weights of pregnant females were found to be significantly heavier (P<0·01) than those of nonparous females. The adrenal weights of male, pregnant and non-pregnant female rats were found to be significantly correlated with their body weights. Results of this study further revealed that changes in adrenal weights inRattus m. pallidior are functions of body weights which are regulated by the availability of food and its nutritional level.