Volume 19, Issue 6
June 1944, pages 189-210
pp 189-203 June 1944
pp 204-210 June 1944
The influence of hook-worm infection on the heart muscle is investigated by perfusing isolated frog hearts with different concentrations of blood sera of patients suffering from Ankylostomiasis.
It is observed that in concentrations of 1 in 106 and 1 in 105 the sera produce a diminution of the Amplitude of the beats indicating the presence of a toxic factor in the sera.
The toxic effect disappears in a few cases after iron therapy and disappears completely or is considerably diminished after anthelmintic treatment.
It is concluded subject to further experimentation that some factor yet to be isolated is present in the blood serum in Ankylostomiasis which exercises a toxic effect on the cardiac muscle and on the blood-forming organs.