Seasonal variation of the interrenal cell-types both in male and femaleRana hexadactyla and the exogenous hormonal effects on the male interrenals have been studied quantitatively. The interrenal cell-types wax and wane throughout the year. A reciprocal relation between the clear and compact cells of the interrenal in both sexes of the frogs has been observed.
The decrease of compact cells and regression of interrenal activity resulting from steroid administration were found to be statistically significant. Concomitant with the decrease of interrenal activity, a regression of interstitium of testis has been noticed.
Pituitary administration stimulates interrenal activity accompanied by an increased spermatogenesis.
A possible role of exogenous steroid and pituitary hormones on the interrenal has been discussed.