• Pyrimidines as possible oncolytic agents - Part I. 2-amino-4-hydroxy-5-(β-hydroxyethyl)-6-alkyl-pyrimidines and 6-alkyl-5-(β-hydroxyethyl)-2-thiouracils

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/seca/068/06/0277-0284

    • Keywords

       

      Pyrimidine; Hydroxyethyl; Colourless Needle; Thiouracil; Sodium Ethoxide

    • Abstract

       

      Two series of 5-(β-hydroxyethyl)-6-alkyl pyrimidines have been synthesised and thirty new compounds reported. Two of the pyrimidines have been found to possess significant tumour inhibitory activity against a solid rat tumour. No relationship between the length of alkyl chain at position ‘6’ in the compounds and their tumour inhibitory activity was observed.

    • Author Affiliations

       

      M V Wagle1 T B Panse1

      1. Chemotherapy Section, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay-12
    • Dates

       
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