On the consideration that stillopsidin is 5-hydroxybutein, butein trimethyl ether has been subjected to nuclear oxidation and final methylation to yield stillopsidin tetramethyl ether. Stillopsidin has now been prepared in better yields by an improved method. The product obtained by the partial demethylation of 2: 4: 5-trimethoxyacetophenone is shown to be 2: 5-dihydroxy-4-methoxyacetophenone which has been prepared by an unequivocal method from pæonol. Similarly an authentic sample of 2: 5-dihydroxy-4-methoxy-benzophenone has been prepared and shown to be the same as that obtained by the partial demethylation of 2: 4: 5-trimethoxybenzophenone. A synthesis of 2:4-dihydroxy-5-methoxyacetophenone has also been carried out.