• Synthetic experiments in the benzopyrone series - Part XXXIX. A note on the synthesis of isogenistein and 8-methyl isogenistein

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      https://www.ias.ac.in/article/fulltext/seca/038/05/0381-0386

    • Keywords

       

      Isoflavone; Acetic Anhydride; Methyl Formate; Mixed Melting Point; Trimethoxy

    • Abstract

       

      It is established that the condensation of 2-hydroxy-4:6:2′-trimethoxy phenyl benzyl ketone and its 3-methyl derivative with ethyl formate as well as with methyl formate produces the corresponding 2-hydroxy isoflavanones. These undergo dehydration to the trimethyl ether of isogenistein and 8-methyl isogenistein respectively. Demethylation of the above ethers can be conveniently effected by aluminium chloride in benzene solution. The 2-hydroxy isoflavanones also yield the same products by undergoing dehydration along with demethylation.

    • Author Affiliations

       

      A C Mehta1 T R Seshadri1 S Varadarajan1

      1. From the Department of Chemistry, Delhi University, India
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