• Synthetic experiments in the benzopyrone series - Part XXIII. A new synthesis of 8-methyl genistein

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      https://www.ias.ac.in/article/fulltext/seca/037/04/0508-0513

    • Keywords

       

      Isoflavone; Aqueous Sodium Hydroxide; Ethyl Formate; Synthetic Experiment; Aqueous Sodium Carbonate

    • Abstract

       

      In view of the discrepancies between the products of the synthesis of 8-methyl genistein described in Part XXII and those of Shriner and Hull, the method of these authors has been re-examined. 2∶4-Dihydroxy-3-methyl-6∶4′-dimethoxy phenyl benzyl ketone and 5∶4′dimethoxy-7-hydroxy-8-methyl isoflavone prepared now are found to have melting points much higher than those reported by Shriner and Hull. However, on methylation, they yield their respective monomethyl ethers which are identical with those described in Part XXII. There is thus complete agreement between the two syntheses.

      The natural compound of Okano and Beppu cannot be 8-methyl genistein. However the degradation reactions could be explained on the

    • Author Affiliations

       

      T R Seshardi1 S Varadarajan1

      1. Department of Chemistry, University of Delhi, Delhi
    • Dates

       
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