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    • Keywords


      Genistein; Monomethyl Ether; Hydrobromic Acid; Anhydrous Potassium Carbonate; Dimethyl Sulphate

    • Abstract


      It is shown that the most convenient method of preparing prunetin is by the partial demethylation of genistein trimethyl ether with hydrobromic or hydriodic acid under controlled conditions. The 5-methyl ether of genistein (isoprunetin) has now been synthesised by the methylation of 7:4′-O-dibenzyl genistein and subsequent debenzylation. Its properties are very different from those of prunetin and it yields a diethyl ether which could be independently prepared from genistein. The present work conclusively proves that prunusetin cannot be 5-O-methyl genistein (isoprunetin) and should be the same as prunetin.

    • Author Affiliations


      N Narasimhachari1 T R Seshadri1 S Sethuraman1

      1. From the Department of Chemistry, Delhi University, India
    • Dates


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