• A new synthesis of menaphthone and lawsone

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    • Keywords


      Lawsone; Quinol; Yellow Needle; Hexamine; Alkaline Hydrogen Peroxide

    • Abstract


      Based on biogenetic considerations new syntheses of menaphthone and lawsone are given. Fromα-naphthol, 1-hydroxy-4-methoxy-2-naphthaldehyde is prepared. This undergoes Clemmensen reduction and subsequent oxidative demethylation with nitric acid to yield menaphthone. On the other hand, Dakin’s oxidation gives directly lawsone and this change involves oxidative demethylation by hydrogen peroxide in alkaline solution. A convenient laboratory method for preparing lawsone employs 2-acetyl-α-naphthohydroquinone.

    • Author Affiliations


      A C Jain1 T R Seshadri1

      1. From the Department of Chemistry, University of Delhi, India
    • Dates


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