Nuclear oxidation in flavones and related compounds - Part XXXVII. Isomerisation of 2:3-dimethyl-5:7:8-trihydroxy chromone
S K Mukerjee T R Seshadri S Varadarajan
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When boiled with hydriodic acid, 2:3-dimethyl-5:7:8-trimethoxy chromone undergoes besides demethylation, isomeric change also, yielding 2:3-dimethyl-5:6:7-trihydroxy chromone, thus showing that a free hydrogen atom in the 3-position is not essential for this isomeric change to take place and that the nature of the substituent is also important. For purposes of comparison, 2:3-dimethyl-5:7:8-trihydroxy chromone has been obtained by demethylation of the above trimethyl ether with aluminium chloride and 2:3-dimethyl-5:6:7-trimethoxy chromone by independent synthesis using nuclear oxidation as a stage.
S K Mukerjee1 T R Seshadri1 S Varadarajan1
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