• Chemotherapy of tuberculosis - Part V. Synthesis of some N4-acyl-N1-aryl sulphanilhydroxamides

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/seca/031/03/0183-0186

    • Keywords

       

      Tuberculosis; Chlorophenyl; Pulmonary Tuberculosis; Sulphanilamide; Sulphapyridine

    • Abstract

       

      A series of sulphanilamides derived from N-carbo and heterocyclic hydroxamides have been synthesised, since a number of N4-acyl sulphanilhydroxamides have been favourably reported on in preliminary experimental bacterial infections. Among the latter wassulphabenamide or N4-caproyl sulphanylhydroxamide, which was said to be effective clinically in streptococcal infections and tuberculosis. This is a new class of sulphanilamides involving the preliminary synthesis of some hitherto unknown substituted aryl- and heterocyclic hydroxamides. The compounds of this series so far prepared are the N4-n-butyryl-, the N4-n-valeryl-, and the N4-n-caproylsulphanilyl derivatives of β-3-chlorophenyl-, β-4-chlorophenyl-, β-2∶5-dichlorophenyl-, and β-3∶4-dichlorophenyl-hydroxylamines.

    • Author Affiliations

       

      C V Deliwala1 S Rajagopalan1

      1. Department of Chemotherapy, Haffkine Institute, Bombay
    • Dates

       
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