• Chemotherapy of Tuberculosis - Part I. Synthesis of possible lipophilic chemotherapeuticals of the sulphonamide and sulphone series derived from fatty acids, including those of the chaulmoogra group

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      https://www.ias.ac.in/article/fulltext/seca/031/01/0021-0025

    • Keywords

       

      Sulphone; Sebacic Acid; Sulphanilamide; Sodium Acetate Solution; Pyridine Solution

    • Abstract

       

      Twenty-three compounds have been synthesised as possible lipophilic chemotherapeuticals of the sulphonamide and sulphone series. Among such compounds are the hydnocarpic acid derivatives of N4-n-fatty acyl sulphanilamides, N4, N1-dihydnocarpylsulphanilamide, normal fatty-acyl derivatives of 4-nitro-4′-amino- and 4∶4′-diamino-diphenylsulphones, 4∶4′-bis-adipylamido- and 4∶4′-bis-sebacylamido-diphenylsulphones, and the N4-n-caproyl derivatives of 2-sulphanilamidopyrimidine, 2-sulphanilamido-4-methyl-and 2-sulphanilamido-4∶6-dimethyl pyrimidines.

    • Author Affiliations

       

      C V Deliwala1 K Ganapathi1 S Rajagopalan1

      1. Department of Chemotherapy, Haffkine Institute, Bombay
    • Dates

       
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