• Nuclear oxidation in flavones and related compounds - Part XXVII. A new synthesis of norwogonin and its methyl ethers

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      https://www.ias.ac.in/article/fulltext/seca/030/06/0342-0347

    • Keywords

       

      Flavone; Chrysin; Wogonin; Hexamine; Alkaline Hydrogen Peroxide

    • Abstract

       

      (1) Chrysin, (2) tectochrysin and (3) 5-O-methyl chrysin are subjected to the two stage oxidation process. All of them give good yields of the corresponding 8-aldehydes. In (2) the 8-position (para) is predominantly more reactive than the 6-position (ortho). In (1) and (3) the favourable influence of a hydroxyl and a methoxyl in the 5-position is exerted. The Dakin’s reaction gives poor yields if the product is a quinol and good yields if it is a catechol. Experiments with (1) and (2) lead to the conclusion that the two stage method is available for para oxidations though the yields are poor.

    • Author Affiliations

       

      T R Seshadri1 S Varadarajan1

      1. Department of Chemistry, Andhra University, Waltair
    • Dates

       
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