• Nuclear oxidation in flavones and related compounds - Part XXIII. A synthesis of kellin

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      https://www.ias.ac.in/article/fulltext/seca/030/03/0107-0113

    • Keywords

       

      Acetic Anhydride; Potassium Carbonate; Chromone; Hexamine; Dimethyl Sulphate

    • Abstract

       

      Kellin (I) has been synthesised starting from 2-methyl-5 ∶ 7-dihydroxychromone (VII). The stages are as follows: (1) treatment with bromacetic ester (VIII); (2) oxidation with alkaline persulphate in which the ester group sets hydrolysed (IX); (3) partial methylation with 2 moles of dimethyl sulphate (X); (4) condensation with hexamine to introduce an aldehyde group in the 6-position (XI); (5) complete methylation (XII); (6) gentle alkali hydrolysis to aldehydo-acid (XIII); and (7) final boiling with acetic anhydride and sodium acetate. Kellin-quinone and nor-kellin have been prepared as convenient derivatives.

    • Author Affiliations

       

      V V Sreerama Murti1 T R Seshadri1

      1. Department of Chemistry, Andhra University, Waltair
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