• Nuclear oxidation in flavones and related compounds - Part XXI. Another synthesis of nobiletin

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    • Keywords


      Flavone; Methyl Ether; Hexamine; Anhydrous Potassium Carbonate; Nobiletin

    • Abstract


      A new synthesis of nobilein has been achieved employing the two stage process of ortho-oxidation. 5∶8-Dihydroxy-7∶3′∶4′-trimethoxy flavone (III) is condensed with hexamine to yield the 6-aldehyde (IV) which undergoes smooth oxidation with hydrogen peroxide to 7∶3′∶4′-trimethyl ether (V) of nornobiletin. Final methylation of (V) produces nobiletin (VI).

    • Author Affiliations


      V V Sreerama Murti1 T R Seshadri1

      1. Department of Chemistry, Andhra University, Waltair
    • Dates


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