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    • Keywords


      Salicylic Acid; Dicarboxylic Acid; Sodium Carbonate Solution; Raney Nickel; Zinc Dust

    • Abstract


      Starting from 4-nitro-o-toluidine, a commercially available dyestuff intermediate, 4-aminosalicylic acid has been prepared in an overall yield of 60 per cent. New derivatives of the acid are described. 3∶3′-Dihydroxyazobenzene-4∶4′-dicarboxylic acid has been obtained from 4-nitrosalicylic acid, an intermediate in the synthesis of 4-aminosalicylic acid. This azo salicylic acid and its O-acetyl derivative are of interest on account of theirin vivo reducibility to 4-aminosalicylic acid and 4-aminoaspirin.

    • Author Affiliations


      D S Bhate1 T B Panse1 K Venkataraman1

      1. Department of Chemical Technology, University of Bombay, India
    • Dates


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