• Nuclear oxidation in the flavone series - Part XI. A new synthesis of nobiletin

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      https://www.ias.ac.in/article/fulltext/seca/027/03/0217-0222

    • Keywords

       

      Flavone; Baicalein; Anhydrous Potassium Carbonate; Nobiletin; Dimethyl Sulphate

    • Abstract

       

      Nobiletin has been synthesised by adopting the method of nuclear oxidation of the flavone skeleton. For this purpose 6-hydroxyluteolin has been prepared for the first time and subjected to partial methylation, oxidation and final methylation successively whereby nobiletin is obtained. Demethylation of this yields nornobiletin having all the propertics described in the literature. Nobiletin has also been prepared independently from 2: 5-dihydroxy-3: 4: 6-trimethoxy-acetophenone by condensation with sodium veratrate and veratric anhydride and subsequent methylation.

    • Author Affiliations

       

      V V Sreerama Murti1 T R Seshadri1

      1. Department of Chemistry, Andhra University, Waltair
    • Dates

       
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