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      Permanent link:
      https://www.ias.ac.in/article/fulltext/seca/024/02/0233-0237

    • Keywords

       

      Anhydrous Potassium Carbonate; Aqueous Alkali; Dimethyl Sulphate; Hydroxy Ketone; Hydriodic Acid

    • Abstract

       

      A method of complete synthesis of 5∶6∶7∶8-hydroxy flavonols is described. It starts from ω∶3∶6-trimethoxy-2∶4-dihydroxy-acetophenone which is subjected to partial methylation (of the 4-hydroxyl group) and subsequently to persulphate oxidation. The product, 2∶5-dihydroxy-ω∶3∶4∶6-tetramethoxy-acetophenone is condensed with the anhydride and sodium salt of anisic acid and also of benzoic acid. The resulting 6-hydroxy-flavones yield on further methylation the fully methylated ethers of calycopteretin and 6∶8-dihydroxy-galangin and on demethylation, the free hydroxy-flavonols.

    • Author Affiliations

       

      V V Sreerama Murti1 L Ramachandra Row1 T R Seshadri1

      1. Department of Chemistry, Andhra University, India
    • Dates

       
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