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    • Keywords


      Flavone; Baicalein; Aqueous Sodium Hydroxide; Hydriodic Acid; Aqueous Sodium Carbonate

    • Abstract


      A simple and at the same time unambiguous method of synthesis of the 5∶6∶7-hydroxyflavones, baicalein and scutellarein and their derivatives is described. It starts from phloracetophenone which is partially methylated to the 4∶6-dimethyl ether. Oxidation of this ether with potassium persulphate yields the 2∶5-dihydroxy compound which on partial methylation produces 2-hydroxy-4∶5∶6-trimethoxyacetophenone. Using the benzoyl and anisoyl derivatives of this ketone and adopting the Baker-Venkataraman procedure, the trimethyl ether of baicalein and the tetramethyl ether of scutellarein have been prepared and from them the hydroxyflavones and their acetates.

    • Author Affiliations


      V D Nageswara Sastri1 T R Seshadri1

      1. Department of Chemistry, Andhra University, India
    • Dates


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