• Synthetic experiments in the benzo-pyrone series - Part I. Synthesis of karanjin-α-carboxylic acid

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      https://www.ias.ac.in/article/fulltext/seca/009/03/0259-0264

    • Keywords

       

      Potassium Carbonate; Sodium Carbonate Solution; Synthetic Experiment; Ethyl Bromoacetate; Alcoholic Ferric Chloride

    • Abstract

       

      2-Methyl-3-methoxy-7-hydroxychromone-8-aldehyde formed a sodium derivative which readily condensed with bromoacetic ester to form the corresponding carbethoxy-methyl ether. This reaction did not take place satisfactorily with 3-methoxy-7-hydroxyflavone-aldehyde. The condensation was, however, smoothly effected in boiling benzene solution in the presence of potassium carbonate. When hydrolysed with aqueous potassium hydroxide, simultaneous ring-closure took place to yield 3-methoxyflavono-7: 8-furan-α-carboxylic acid which is considered to be karanjin-α-carboxylic acid.

    • Author Affiliations

       

      S Rangaswami1 T R Seshadri1

      1. Department of Chemistry, Andhra University, Waltair
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