• An improved ant-based algorithm based on heaps merging and fuzzy c-means for clustering cancer gene expression data

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    • Keywords


      Gene expression data; gene selection; clustering; ant-based clustering; correlation-based feature selection; hybrid algorithms

    • Abstract


      The microarray technology enables the analysis of the gene expression data and the understanding of the important biological processes in an efficient way. We have developed an efficient clustering scheme for microarray gene expression data based on correlation-based feature selection, ant-based clustering, fuzzyc-means algorithm and a novel heaps merging heuristic. The algorithm utilizes the feature selection algorithm to overcome the high-dimensionality problem encountered in bioinformatics domain. Based on extensive empiricalanalysis on microarray data, clustering quality of the ant-based clustering algorithm is enhanced with the use of fuzzy c-means algorithm and heaps merging heuristic. The performance of the proposed clustering scheme iscompared with k-means, PAM algorithm, CLARA, self-organizing map,hierarchical clustering, divisive analysis clustering, self-organizing tree algorithm, hybrid hierarchical clustering, consensus clustering, AntClass algorithm and fuzzy c-means clustering algorithms. The experimental results indicate that the proposed clustering scheme yields better performance in clustering cancer gene expression data.

    • Author Affiliations



      1. Department of Computer Engineering, Ege University, Izmir, Turkey
      2. Department of Computer Engineering, Izmir Katip Celebi University, Izmir, Turkey
    • Dates

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