Nowadays, the number of software vulnerabilities incidents and the loss due to occurrence of software vulnerabilities are growing exponentially. The current existing security strategies, the vulnerability detection and remediating approaches are not intelligent, automated, self-managed and not competent to combat against the vulnerabilities and security threats, and to provide secured self-managed software environment to the organizations. Hence, there is a strong need to devise an intelligent and automated approach to optimize security and prevent the occurrence of vulnerabilities or mitigate the vulnerabilities. The autonomic computing is a nature-inspired and self-management-based computational model. In this paper, an autonomic-computing-based integrated framework is proposed to detect, fire the trigger of alarm, assess, classify, prioritize, mitigate and manage the software vulnerability automatically. The proposed framework uses a knowledge base and inference engine, which automatically takes the remediating actions on future occurrence of software security vulnerabilities through self-configuration, self-healing, self-prevention and self-optimization as per the needs. The proposed framework is beneficial to industry and society in various aspects because it is an integrated, crossconcern and intelligent framework and provides more secured self-managed environment to the organizations. The proposed framework reduces the security risks and threats, and also monetary and reputational loss. It canbe embedded easily in existing software and incorporated or implemented as an inbuilt integral component of the new software during software development.