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      https://www.ias.ac.in/article/fulltext/sadh/031/02/0105-0115

    • Keywords

       

      Dendrogram; hierarchical clustering; horizontally acquired genes; oligonucleotide distributions; statistical test of significance; transposons

    • Abstract

       

      Vibrio cholerae, Vibrio vulnificus, Vibrio parahaemolyticus and several other relatedVibrio species show distinctly similar two-chromosomal genome organization. However, the modes of pathogenicity are very different among these species, and this is largely attributed to externally acquired genetic elements. We develop some statistical methods to determine these external genetic elements or genomic islands in genomes based on their differential oligonucleotide usage patterns compared to the rest of the genome. Genomic islands identified by these unsupervised statistical methods include integron and pathogenicity islands. After statistical determination of the genomic islands, we investigate their gene contents and their possible association with the pathogenic behaviour of the correspondingVibrio species. These investigations lead to observations that are of evolutionary and biological significance.

    • Author Affiliations

       

      Sanjay Nag1 Raghunath Chatterjee1 Keya Chaudhuri1 Probal Chaudhuri2

      1. Human Genetics & Genomics Group, Indian Institute of Chemical Biology, Jadavpur, Kolkata - 700 032, India
      2. Theoretical Statistics and Mathematics Unit, Indian Statistical Institute, 203, BT Road, Kolkata - 700 108, India
    • Dates

       
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