Minor deviations in the script of human life (the genetic code) are known to have major consequences on human health and wellbeing. Even substitution of a single nucleotide (single nucleotide polymorphism – SNP) in the gene sequences can cause diseases. SNP genotyping refers to a variety of techniques that allow simultaneous detection of such changes that can be associated with the pathophysiology of different diseases. However, most of the current, cutting-edge SNP geno-typing technologies are complex, expensive, and require post-PCR manipulation. The Tetra–Amplification-Refractory Mutation System–Polymerase Chain Reaction (T-ARMS-PCR) method is a simple tool that meets modern diagnostic labo-ratories’ expectations. It is a fast, reliable, and economical method of genotyping for genetic diseases such as $\beta$-thalassemia.