• Cell Mechanosensing : Response of Living Cells to Their Mechanical Environment

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    • Keywords


      Mechanobiology, cell adhesion, mole- cular bond dynamics, stochastic process, master equation.

    • Abstract


      Mechanical forces are known to play important roles in determining cellular functions and behaviours such as growth, migration, wound healing and tissue regeneration, to name a few. It is quite intriguing how cells sense the mechanical forces and properties of the surrounding matrix in which the cells float or rest. The cells are known to build numerous ‘adhesion contacts’ at the cell-matrix interface to probe the surroundings. These adhesion contacts, known as ‘focal adhesions’ are highly dynamic and strongly force sensitive. In this article, we discuss about the focal adhesions which act as mechanosensors and, in turn, regulate cellular activity.

    • Author Affiliations


      Rumi De1

      1. Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar, PO Manauli, Punjab 140 306, India.
    • Dates


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