• Making Worms Glow: DNA Nanomachines in Caenorhabditis elegans

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    • Keywords


      Nanotechnology, nanomachines, I-switch, FRET, fluorophore, endocytosis, pH sensor, C.elegans.

    • Abstract


      Deoxyribonucleic acid (DNA) is the molecule that carries geneticinformation in a cell. The field of DNA nanotechnologyaims to use DNA as the basis for making complex nanometerscalestructures. While much progress has been made in creatingsuch nano-architectures, the use of these structureswithin organisms had never been attempted. Our work is focusedon using a simple DNA-based pH sensor in worms toyield information about organelle activity in cells. The firstof its kind, this work set up a system to use DNA as a probein living systems.

    • Author Affiliations


      Sunaina Surana1 Yamuna Krishnan2

      1. Sobell Department of Motor Neuroscience and Movement Disorders Institute of Neurology University College London Queen Square London WC1N 3BG, UK.
      2. Gordon Centre for Integrative Science 929 E., 57th Ellis Avenue Department of Chemistry University of Chicago Chicago 60637, USA.
    • Dates


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