• DNA Repair Systems: Guardians of the Genome

    • Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/reso/021/10/0925-0936

    • Keywords

       

      DNA repair, DNA damage, base excision repair, nucleotide excision repair, methyl-directed mismatch repair, Nobel Prize.

    • Abstract

       

      The 2015 Nobel Prize in Chemistry was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar to honour their accomplishments in the field of DNA repair. Ever since the discovery of DNA structure and their importance in the storage of genetic information, questions about their stability became pertinent. A molecule which is crucial for the development and propagation of an organism must be closely monitored so that the genetic information is not corrupted. Thanks to the pioneering research work of Lindahl, Sancar, Modrich and their colleagues, we now have an holistic awareness of how DNA damage occurs and how the damage is rectified in bacteria as well as in higher organisms including human beings. A comprehensive understanding of DNA repair has proven crucial in the fight against cancer and other debilitating diseases.

    • Dates

       
  • Resonance – Journal of Science Education | News

© 2017-2019 Indian Academy of Sciences, Bengaluru.