By employing the Nikiforov–Uvarov functional analysis (NUFA) method, we solved the radial Schrödinger equation with the shifted Morse potential model. The analytical expressions of the energy eigenvalues, eigenfunctions and numerical results were determined for selected values of the potential parameters. Variations of different thermodynamic functions with temperature were discussed extensively. Different quantum information theoretic measures, including Shannon entropy, Fisher information and Fisher–Shannon product of the shifted Morse potential, were investigated numerically and graphically in position and momentum spaces for the ground and the first excited states. The quantum information theories considered satisfied their corresponding inequalities, including Bialynicki–Birula–Mycielski, Stam–Cramer–Rao inequalities and the Fisher–Shannon product relation.