Two-dimensional magneto-Sisko nanofluid flow bounded by nonlinearly stretching sheet is studied. Thermophoretic diffusion and Brownian motion effects are also scrutinised. Additionally, impacts of activation energy, chemical reaction and nonlinear convection are considered. The purpose of this study is to analyse entropy generation in the Sisko fluid model. Suitable transformations are used to reduce the governing equation of motion, concentration and temperature. Effects of some pertinent variables on skin friction coefficient, temperature, velocity, concentration and Nusselt number are graphically presented. Clearly, for larger Brownian and thermophoresis parameters, the temperature increases while concentration distribution decreases with Brownian parameter. Bejan number is maximum away from the sheet in the case of shear thickening fluids while it approaches zero for shear thinning fluids.