This paper investigates the electro-osmotic flow of non-Newtonian nanofluid through a peristaltic microchannel by considering the influence of electro-osmotic phenomenon. The effects of the Brownian and thermophoresis parameters are taken into account. The problem is modulated and its governing equations are solved analytically by assuming long wavelength and low Reynolds number. The distributions of the axial velocity, temperature, nanoparticles volume fraction and volumetric flow rate are achieved and plotted under the influence of various parameters. In addition, the expressions for the skin friction, Nusselt number and Sherwood number are obtained and illustrated through a set of graphs. Furthermore, the trapping phenomenon is examined with the Rayleigh, Brownian and thermophoresis parameters. The present results are useful in medical and biological applications, especially in cancer therapy, which involves suspended nanoparticles of gold in blood (nanofluid)passing through a peristaltic tube (artery).