A theoretical study of the nuclear reaction cross-section for the production of ⁶⁴Cu and ⁸⁶Y was performed from the nuclear reactions ⁶⁴Ni(p, n)⁶⁴Cu, ⁶⁴Ni(d, 2n)⁶⁴Cu, ⁶⁶Zn(d, 𝛼)⁶⁴Cu, ⁶⁸Zn(p, n𝛼)⁶⁴Cu, ⁸⁶Sr(p, n)^86gY, ⁸⁷Sr(p, 2n)^86gY and ⁸⁸Sr(p, 3n)^86gY. The calculations were performed using three codes EMPIRE, TALYS and ALICE-IPPE. The excitation function curves for the investigated reactions have been constructed from the enriched targets using ⁶⁴Ni, ⁶⁶Zn, ⁶⁸Zn, ⁸⁶Sr, ⁸⁷Sr and ⁸⁸Sr. The calculated excitation functions and the experimental data were compared. Mean standardized deviation, mean relative deviation and mean ratio statistical parameters were introduced to control the quality of the fitting between both the experimentally and the theoretically calculated cross-sections.