Energy calibration of superheated droplet detector is discussed in terms of the effective recoil nucleus threshold energy and the reduced superheat. This provides a universal energy calibration curve valid for different liquids used in this type of detector. Two widely used liquids, R114 and C₄F₁₀, one for neutron detection and the other for weakly interacting massive particles (WIMPs) dark matter search experiment, have been compared. Liquid having recoil nuclei with larger values of linear energy transfer (LET) provides better neutron-𝛾 discrimination. Gamma (𝛾) response of C₄F₁₀ has also been studied and the results are discussed. Behaviour of nucleation parameter with the effective recoil nucleus threshold energy and the reduced superheat have been explored.