Monodisperse poly(N -isopropylacrylamide) (PNIPAM) particles loaded with cadmium telluride (CdTe) quantum dots (QDs) of two different sizes (4.7 nm and 5.6 nm) were synthesized in aqueous medium by bonding the capping agent on the quantum dots to the amide groups of PNIPAM and incubating the samples at 45° C. A huge increase in the photoluminescence (PL) intensity (green and red regions) is observed for the PNIPAM–CdTe QDs composites compared to the parent CdTe QDs. We report here for the first time the imaging of binary dispersion of green and red luminescent PNIPAM–CdTe QDs composites using a fluorescence confocal laser scanning microscope. These composites have potential applications both in material science and biology.