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      https://www.ias.ac.in/article/fulltext/pram/071/05/0991-0995

    • Keywords

       

      Micelles; polymer solutions; neutron scattering.

    • Abstract

       

      Self-assembling behaviour of block copolymers and their ability to evade the immune system through polyethylene oxide stealth makes it an attractive candidate for drug encapsulation. Micelles formed by polyethylene oxide–polypropylene oxide–polyethylene oxide triblock copolymers (PEO–PPO–PEO), pluronic P123, have been employed for encapsulating the anti-cancer drug doxorubicin hydrochloride. The binding affinity of doxorubicin within the micelle carrier is enhanced through complex formation of drug and anionic surfactant, aerosol OT (AOT). Electrostatic binding of doxorubicin with negatively charged surfactants leads to the formation of hydrophobic drug–surfactant complexes. Surfactant-induced partitioning of the anti-cancer drug into nonpolar solvents such as chloroform is investigated. SANS measurements were performed on pluronic P123 mi-celles in the presence of drug–surfactant complex. No significant changes in the structure of the micelles are observed upon drug encapsulation. This demonstrates that surfactant–drug complexes can be encapsulated in block copolymer micelles without disrupting the structure of aggregates.

    • Author Affiliations

       

      Jayita Bhattacharjee1 Gunjan Verma1 V K Aswal2 P A Hassan1

      1. Chemistry Division; Bhabha Atomic Research Centre, Mumbai 400 085, India
      2. Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
    • Dates

       
  • Pramana – Journal of Physics | News

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      Posted on July 25, 2019

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