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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/plnt/087/10/0257-0259

    • Keywords

       

      L-[U-14C]-2; 3-diaminopropionate; metabolism; rat; respiratory CO2; liver; neurotoxic derivatives

    • Abstract

       

      L-[U-14C]-2, 3-diaminopropionate was metabolised slowly in the rat. Nearly 75% of the total radioactivity could be accounted for by respiratory CO2 (60%) and by the concentration of the isotope in the liver and kidney (15%). The rate limiting step in its metabolism may be the activity of 2, 3-diaminopropionate: ammonia lyase in the liver. It is more readily metabolised than its 3-oxalyl derivative, which is neurotoxic.

    • Author Affiliations

       

      K R Vijayalakshmi1 K Hariharan1 D Rajagopal Rao1

      1. Discipline of Biochemistry and Applied Nutrition, Central Food Technological Research Institute, Mysore - 570013

    • Dates

       
      Published
      October 1978
      Manuscript received
      3 June 1978
      Final version published online
      2 January 2014
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