• Effect of cadmium chloride on the serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and androgens in the adult male rat

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      https://www.ias.ac.in/article/fulltext/plnt/087/07/0161-0167

    • Keywords

       

      Cadmium chloride; follicle stimulating hormone; luteinizing hormone; androgens; rat

    • Abstract

       

      Adult male rats injected with cadmium chloride were compared with controls with respect to serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), androgens and testicular histology. A single injection of cadmium chloride (9 mg/kg) was found to bring about no consistent short term changes in the plasma levels of FSH or LH, but after a long period the levels of both these hormones were elevated. In contrast, the levels of androgen showed a sharp increase at 6 h which declined by 12 h. In accordance with the elevated levels of gonadotropins found at 9–28 days after cadmium chloride injection, the androgen levels showed a drastic reduction. Histological aspect of the testis revealed acute necrotic changes of which the vacuolation of spermatid nuclei and fibrosis of Leydig cells are noteworthy.

    • Author Affiliations

       

      N H Gopal Dutt1 K Wakabayashi2 S Inoue2

      1. Post-graduate Department of Zoology, University of Mysore, Manasagangotri, Mysore - 570 006
      2. Institute of Endocrinology, Gunma University, Maebashi, Japan
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