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    • Keywords


      Hb D-Punjab; sickle cell disease; BP1U motif; unicentric origin of tribes; double heterozygous HbSD.

    • Abstract


      Origin and ancestry of the Badagas of Nilgiris, an indigenous community of Nilgiris, Tamil Nadu in India, is a controversial topic. During our massive screening for haemoglobinopathies among Badagas, we identified a rare south Indian haemoglobin variant, the haemoglobin D (Hb D) Punjab (HBB: c.364G>C; rs33946267). The observed Hb D cases were double heterozygous with sickle cell trait (HbSD-Punjab) and manifested symptoms. The beta-globin distal promoter motif (-530 cap site BP1U) sequencing revealed a characteristicheterozygous combination of Arab-Indian sickle haplotype ((AT)9 (T)5) with universally common beta gene haplotype ((AT)7 (T)7). The report is a pioneer one informing the presence of Hb–D Punjab from an indigenous or aboriginal group of southern India. By the above information, we support the theory of unicentric tribal origin and distribution during Harappan civilization.

    • Author Affiliations



      1. Molecular Biodiversity Lab, Department of Zoology and Wildlife Biology, Government Arts College, Udhagamandalam 643 002, India
      2. Department of Zoology, Providence College for Women, Spring Field P.O., Coonoor 643 104, India
    • Dates

  • Journal of Genetics | News

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      Posted on July 25, 2019

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