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      https://www.ias.ac.in/article/fulltext/jgen/100/0040

    • Keywords

       

      Dandy–Walker malformation; prenatal diagnosis; trisomy 12p; chromosomal microarray analysis.

    • Abstract

       

      Dandy–Walker malformation (DWM) is characterized by complete or partial agenesis of the cerebellar vermis, cyatic dilatation of the forth ventricle, and enlarged posterior fossa. However, the mechanism is still not completely understood up to now. In this study, we reported a rare case that a foetus with DWM showed partial trisomy 12p and distal 15q deletion. Karyotype analysis and chromosomal microarray analysis (CMA) were not always concordant with each other, and it is suggested that they should be performed for prenatal genetic diagnosis together. DWM is a rare central nervous system malformation, reported in 1/25–30,000 live births, characterized by complete or partial agenesis of the cerebellar vermis, cyatic dilatation of the forth ventricle, and enlarged posterior fossa (Kumar et al. 2001; Klein et al. 2003; Agrawal et al. 2016). The neurological development of children with DWM may range from normal to severely retarded, and cause variable clinical feature. Although several efforts have been made to explore its pathogenesis, however, it is still not completelyunderstood. During the past decade, some genetic loci, microdeletion or duplication have been reported to be associated with DWM, suchas 9p trisomy, partial deletions of the long arm of chromosome 13, genes ZIC1 and ZIC4 (von Kaisenberg et al. 2000; McCormack et al. 2003; Grinberg et al. 2004). In the present study, we describe a prenatal diagnosis case that a foetus with DWM on ultrasound scanning accepted genetic testing, and it revealed a microduplication of 12p13.33p11.1 and microdeletion of 15q11.2 in 750K single nucleotide polymorphism (SNP) array, while it showed 46,XX,der(8)(8pter→8q24::12p10→12qter),i(12)(p10) in karyotyping.

    • Author Affiliations

       

      YANMEI SUN1 NING ZHANG1 HAISHEN TIAN1 PINGPING ZHANG1 YALI LI1

      1. Department of Reproductive and Genetics, Hebei General Hospital, Hebei Province, No. 348 West Heping Road, Shijiazhuang 050051, People’s Republic of China
    • Dates

       
  • Journal of Genetics | News

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