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    • Keywords

       

      male infertility; spermatogenesis; Y-chromosome; microdeletion; azoospermia factor; spermatogenesis.

    • Abstract

       

      Deletion of specific genes present in the long arm of Y chromosome has been identified as the most common genetic cause of defective spermatogenesis. Studies have shown that frequency of Y chromosome microdeletion varies in different geographical location and is related to genetic and environmental influence preponderance. Therefore, the present study was carried out to identify the frequency of Y chromosome microdeletion in the northern region of India and to define subgroup of infertile patients who are critically under more risk of having microdeletion. A total of 292 north Indian infertile males with nonobstructive azoospermia and oligozoospermia were selected for screening the Y chromosome microdeletion. Healthy fertile males (n=100) were also enrolled as control subjects. Frequency of Y chromosome microdeletion in north Indian infertile males was found to be about 8.5%, with azoospermia factor (AZFc) region as the most susceptible region for microdeletion. Comparatively microdeletion is more common in patients with nonobstructive azoospermia thanoligozoospermia (9.2% versus 7.1%). Statistical analysis also revealed that patients with hormonal FSH level between 20 and 40 mIU/mL have more chances of harbouring microdeletion. Hence, the present study highlights the importance of screening AZFc region among infertile patients with very high serum FSH value.

    • Author Affiliations

       

      HIMANSHU SHARMA1 2 UJJAWAL SHARMA2 SANTOSH KUMAR3 SHRAWAN KUMAR SINGH3 RAVI MOHAN S. MAVADURU3 RAJENDRA PRASAD2 4

      1. Department of Biochemistry, All India Institute of Medical Science, Bathinda 151 001, India
      2. Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh 160 012, India
      3. Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh 160 012, India
      4. Department of Biochemistry, Maharishi Markandeswar Institute of Medical Sciences and Research, Mullana, Ambala 133 207, India
    • Dates

       
  • Journal of Genetics | News

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