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      https://www.ias.ac.in/article/fulltext/jgen/100/0021

    • Keywords

       

      tumour; miRNA sponge; back-splicing; biomarker.

    • Abstract

       

      Circular RNAs (circRNAs) are a class of noncoding RNA molecules formed by the back splicing process. Compared to linear mRNA molecules they are more stable. CircRNA acts as miRNA sponges, regulates translation, epigenetic alterations, etc. However, the most significant aspect of circRNAs has been its role in regulating the hallmark of cancer and diabetes mellitus. Several circRNAs areextensively expressed in individuals with cancer and diabetics. Dysregulated expression of various circRNAs plays a crucial part in the development of type 2 diabetes mellitus. In the present review, we present the current understanding of cricRNAs biogenesis, regulatory mechanisms, reviews of recent findings and circRNA as potential biomarker.

    • Author Affiliations

       

      ANIMESH HATIBARUAH1 MIZANUR RAHMAN1 SATYAKAM AGARWALA1 SINGH ANI SERAM1 SURUCHI GUPTA2 PROSENJIT PAUL PAUL3

      1. University of Science and Technology, Nongpoh, Meghalaya 793 101, India
      2. CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, India
      3. Negeome Bio Solutions Pvt. Ltd., Jalukbari, Guwahati 781 012, India
    • Dates

       
  • Journal of Genetics | News

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