• Analysis of indigenous plasmid sequences of A. baumannii DS002 reveals the existence of lateral mobility and extensive genetic recombination among Acinetobacter plasmids

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    • Keywords

       

      horizontal gene transfer; plasmid incompatibility; Acinetobacter, sp. mobile genetic elements; gene sharing network.

    • Abstract

       

      Genome sequence of Acinetobacter baumannii DS002 revealed the existence of seven contigs with features of indigenousplasmids. Of the seven contigs, three of them have shown size and sequence identity. They appeared to have been generated due to theunique recombination events leading to a large-scale recombination and sequence inversions. The rest of the indigenous plasmids haveshown significant size variations and contained the genetic repertoire required for the detoxification of formaldehyde and biosynthesis ofexopolysaccharides. Genetic modules encoding novel toxin–antitoxin systems were found in most of the plasmids to ensure their survival inthe host. In some instances, the toxin and antitoxin coding sequences were found on two different plasmids promoting the cosegregation ofthese two plasmids into the daughter cells.

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  • Journal of Genetics | News

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