Updating and identifying three novel variants of the CARD14 gene in Chinese Han patients with psoriasis
YIKE HUANG CHENHUI ZHANG LU TAO JIAQING ZHOU JIE ZHU KEXIANG YAN LING HAN QIONG HUANG JINXIU SHI ZHENGHUA ZHANG
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Psoriasis-2 (PSORS2) is caused by the heterozygous mutation of the caspase recruitment domain 14 (CARD14) gene on chromosome 17q25. To evaluate the contribution of CARD14 variants in psoriasis of the Chinese Han population, we performed deep sequencing of the CARD14 gene in 372 Chinese Han patients with psoriasis. The exonic nucleotide variants were confirmed by Sanger sequencing in the affected individuals and 1114 controls. In 27 patients with psoriasis, we identified 15 variations, including three novel variants: c.381C[G (p.Cys127Trp), c.712A[G (p.Met238Val) and c.2260_2261delinsGG (p.Gln754Gly). These findings could enrich and update the Human Gene Mutation Database of CARD14 variants for psoriasis.
YIKE HUANG1 2 3 CHENHUI ZHANG2 LU TAO1 JIAQING ZHOU1 JIE ZHU1 KEXIANG YAN1 LING HAN1 QIONG HUANG1 JINXIU SHI2 ZHENGHUA ZHANG1
Volume 99, 2020
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