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      https://www.ias.ac.in/article/fulltext/jgen/099/0048

    • Keywords

       

      HOX transcript antisense intergenic RNA; polymorphism; cancer; meta-analysis.

    • Abstract

       

      Several recent investigations show that HOX transcript antisense intergenic RNA (HOTAIR) play an important role in the pathogenesis of different cancers. HOTAIR polymorphisms has been widely studied in the context of association between with the risk of cancer pathogenesis. However, there is no certain conclusion about the role of HOTAIR polymorphisms in different cancer initiation and progression. Our team has selected eligible studies up to 1 May 2019, from several electronic databases, including Web of Science, PubMed, Scopus, and Google Scholar databases. We have included total number of 102 case–control investigations extracted from 41 eligible articles for the current meta-analysis. We calculated pooled odds ratio (ORs) with their corresponding 95% confidence intervals (CIs) using either fixed-effect or random-effect models for quantitative evaluation of the strength for the association between HOTAIR gene polymorphisms and the risk of cancer. Our current meta-analysis investigation showed that HOTAIR rs4759314 polymorphism particularly increased the overall risk of cancer in different models including homozygous, recessive and allele genetic. HOTAIR rs920778 significantly raised the cancer risk only in recessive genetic model. HOTAIR rs12826786 polymorphism was associated with cancer development in heterozygous, homozygous, dominant, recessive and allele genetic models. Also, an increase in cancer risk was observed with rs874945 polymorphism of HOTAIR gene in heterozygous, dominant and allele genetic models. The rs12427129 polymorphism showed correlation with cancer susceptibility only in recessive model. Subgroup analysis based on cancer type suggested that rs4759314 polymorphism significantly increased the risk of gastric and cervical cancers, and the rs920778 polymorphism increased the risk of gastrointestinal, cervical and gastric cancers. In summary, this study found that HOTAIR polymorphisms are significantly associated with cancer development.

    • Author Affiliations

       

      ABDOLKARIM MOAZENI-ROODI1 SAJJAD AFTABI2 3 SAHEL SARABANDI4 SHIMA KARAMI4 MOHAMMAD HASHEMI4 5 SAEID GHAVAMI3 6

      1. Department of Clinical Biochemistry, Iranshahr University of Medical Sciences, Iranshahr 9914786138, Iran
      2. Medical Physics Department, CancerCare Manitoba, Winnipeg, MB R3E 0V9, Canada
      3. Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
      4. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran
      5. Genetics of Non-communicable Disease Research Centre, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran
      6. Research Institute in Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg R3E 0J9, Canada
    • Dates

       
  • Journal of Genetics | News

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